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PLAGUE

JAMA published a consensus article covering plague as a biological weapon.  The pdf file is available here: Plague

PlagueCardHospital.pdf
  • Yersinia pestis is available worldwide; it can be mass produced; it can be disseminated using an aerosol; it has a high fatality rate (pneumonic form); and it has a potential for person to person transmission.
  • The first plague pandemic was in 541AD and killed about 50% of the European population.  The second plague pandemic started in 1346 and killed 20 million over the next 130 years.  The third pandemic began in China in 1855 and killed 12million in Asia.  Plague infested fleas were used by the Japanese against the Chinese in WWII. 
  • Plague is endemic in some parts of the US.  Naturally occurring plague results from flea bites and past epidemics have been associated with large numbers of rodents deaths because the plague is an enzootic in rats, squirrels, prairie dogs, and other rodents.  From 1947 to 1996 there were 390 cases of plague in the US. In 1995, an Ohio microbiologist was arrested after he fraudulently obtained Y pestis through the mail.
  • Pneumonic plague can be transmitted from person to person.  In 1997 a patient in Madagascar with bubonic plague and secondary pneumonic infection transmitted pneumonic plague to 18 others, 8 of whom died.
  • After an aerosol dissemination of plague people will begin to present within 1-7 days.  Many cases from an aerosol dispersal of plague will follow a rapidly fatal course.

 

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